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Content:

A huge number of lifestyle and environmental factors lead to erectile dysfunction in men. This problem greatly affects both the physical health of a man and his morale. After all, if a man cannot have a full-fledged sex life, his emotional state and self-confidence drop significantly. Fortunately, there are many ways to solve this problem, we will talk about them in more detail.

To improve and enhance male strength, it is very important to lead an active lifestyle, not have bad habits, and experience less stressful situations, a variety of drugs can also help with this. Viagra can be one of these. It is the last word on the production of drugs of this kind, has a long-term effect, it is safe, and has very few side effects. Viagra, the first effective drug for the treatment of erectile dysfunction (ED), appeared in 1998 and literally “blew up” the market. In 2000, Viagra accounted for 90% of sales of drugs to improve potency.

In April 1998, Sildenafil citrate, widely known under the trade name Viagra, was approved by the FDA for clinical use. This moment did not just become the starting point for the existence of another drug on the pharmacological market. It turned out to be the beginning of a new era in the field of sexual medicine, marked by a real breakthrough in the fundamental and clinical fields, as well as in the public perception of sexual pathology.

What is Viagra?

Viagra is a drug designed to treat erectile dysfunction in men. Viagra is a powerful and selective inhibitor of cycloguanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5).

The pharmacological effect of this therapeutic action works by releasing nitric oxide (NO) in the corpora cavernosa through sexual stimulation. As a result of this, blood flow to the penis is increased and its smooth muscle fibers are relaxed.

Viagra is the Best Drug for Men

The drug is created for men and has the only indication for use: treatment of erectile dysfunction. The advent of Viagra has changed the lives of millions of men in the world. Patients with erectile dysfunction thanks to it return to a normal sexual life. The clinical effectiveness of Viagra has been confirmed by numerous world studies.Let’s give an example of one of the clinical trials: 12 weeks after the start of taking the drug, an improvement in erection is noted by 76% of patients who received Viagra and 22% of those who received a placebo.

How Viagra Works in the Body

Viagra contains the active ingredient Sildenafil. The drug is produced in tablets of three dosages – 25 mg, 50 mg, and 100 mg. Viagra acts in the body through a complex chain of biochemical reactions. As a result, they lead to the relaxation of the muscular walls of the vessels of the cavernous bodies in the penis and fill them with blood. This ensures a natural response to sexual arousal.

It is important to understand that Viagra does not treat the cause of erectile dysfunction (ED), it simply helps to cope with the consequences. Viagra does not increase sexual desire. If there is no attraction to a partner, then the medicine is useless.

How Effective is Viagra for Treating Sexual Problems in Men?

Viagra was the first drug approved for the treatment of sexual problems in men. The clinical effectiveness of Viagra has been evaluated in a large number of studies conducted in many countries around the world. Taking the drug leads to an improvement in erectile function in patients of different ages, regardless of the etiology, severity and duration of ED. The effectiveness of the drug is long-term, and the vast majority of patients continue taking Viagra years after the start of treatment.

More than 90% of men note the effectiveness of these drugs and do not require any additional treatment.

Viagra has a number of advantages. The positive properties of Viagra include quick inclusion in the work (it begins to act after 40-50 minutes after taking it), a fairly long period of action (about 4-6 hours), and a tangible effect (according to the reviews of men who took Viagra, one feels a real and lasting effect).

Research Work of Viagra

What does the mechanism of erection look like in terms of biochemistry? Sexual arousal leads to the release of nitric oxide NO in the tissues of the penis. The oxide, in turn, leads to the formation of cyclic guanosine monophosphate, which causes relaxation of the smooth muscles of the penis. Blood fills the dilated vessels and an erection occurs. At the same time, phosphodiesterase type 5 cleaves cyclic GMF, after which the smooth muscles contract, blood flows out of the cavernous bodies, and the penis falls off.

From all this, at least, two conclusions can be drawn. First, a morning erection is not necessarily a consequence of sexual arousal, but rather a complete relaxation of smooth muscles during sleep. Secondly, if during the process of excitation in the necessary tissues a sufficient amount of nitric oxide has not been produced, it can be delivered there chemically.

Viagra, unfortunately, does not work that way, otherwise it would be possible to cause an erection regardless of the desire. Blue tablets, being a powerful selective PDE5 inhibitor, prevent the breakdown of cGMP in the tissues of the penis. It prolongs the erection, but the production of nitric oxide still remains on the responsibility of the owner of the penis. Nothing will come of it without sexual arousal. To date, the extension of erection with the help of sildenafil is the most technologically advanced and harmless method.

What You Need to Know Before Taking Viagra

Persons who should not take Viagra:

• Elderly people should consult with specialists before using Viagra.
• The drug should not be taken by people with hypersensitivity to sildenafil and taking medications that contain nitrates.
• It is contraindicated in men with lactose intolerance or deficiency.
• It is especially dangerous to take the drug for people with severe cardiovascular diseases and arterial hypotension.
• If you have an allergic reaction to it.

You should be wary of the combined use of Viagra and another remedy for male potency, as this has not yet been sufficiently studied. Co-administration of ritonavir is contraindicated.

According to the registered indication, the drug is not intended for use by children under 18 years of age and women. Elderly people are advised to consult with specialists before use.

How to Take Viagra?

Viagra is taken 30 minutes or 1 hour before sexual intercourse, on an empty stomach. You can also take it 4 hours before sexual activity. Viagra will show its therapeutic effect only if you apply sexual stimulation.

Viagra can only be taken once a day.

Dosage of Viagra: instructions

Usual dose for adults with ED:

Initial dose: 50 mg orally one time a day, 1 hour before sexual activity.

Maintenance dose: 25 to 100 mg orally one time a day, 1 hour before sexual activity.

Data from the study of the drug showed that increasing the dose to 200 mg did not lead to an increase in the effect, but side effects became more frequent (headache, “hot flashes”, dizziness, stomach problems, nasal congestion, visual disturbances).

Dose for elderly with ED:

Initial dose: 25 mg orally one time a day, 1 hour before sexual activity.

The recommended dose may be reduced to 25 mg or increased to 100 mg, depending on the effectiveness, tolerability of the drug and diseases in the patient.

How Long Does the Effect of Viagra Last?

Knowing how long the drug will take effect and how long the effect will last is very important. This will help a man to plan his time more carefully.

There is no exact answer to this question. There are pills with different content of the substance, moreover, all male organisms are different. Therefore, the effect may vary from person to person.

On average, according to men, the work of Viagra lasts up to 4-5 hours, and the effect begins to gradually subside after 2 hours. However, there are also cases when the potency remedy works all night, giving the user the opportunity for an unlimited number of sexual acts. In any case, the effect will subside after a while or after prolonged ejaculation.

Common Side Effects of Viagra

The use of the drug, even if you have not noticed any contraindications to the use of the drug, can lead to certain negative consequences. As a rule, these consequences from taking the remedy proceed without pronounced severity and pass quite quickly. There are just few side effects of the drug, which include headaches, indigestion, skin redness, dizziness and diarrhea. These common side effects are mild and last about 5 hours. But exceeding the dosage of the drug can increase the duration and intensity of adverse reactions.

Only 10% of men who used Viagra noticed common side effects. But they appeared in a weak form.

What Happens if You Regularly Take a Remedy

It is not worth getting used to the drug. It has an effect on the body, being a potent agent. Moreover, over time, the body will begin to get used to Viagra, and, as a result, the effect will slowly fade away. With long-term use of Viagra, problems in the cardiovascular system may begin.

How to Buy Viagra Online

There are many places where you can buy Viagra, but it is not always available to everyone, as it is available by prescription, after an examination by a doctor, and many men are embarrassed to go to a doctor with a problem related to erectile dysfunction. But nowadays this problem can be easily resolved. The best option to buy Viagra without a prescription is the purchase of the drug in online stores, we can recommend buying Viagra in the trusted online pharmacy, every man can order Viagra (Sildenafil) there.

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To order this medication, you need to follow the link and to enter the name in the search bar of the pharmacy site or find it in the section with drugs of the corresponding action. After that, you need to select all the parameters of the tool and wait for communication with the manager to clarify the delivery details.

Thanks to cooperation with regular suppliers, online pharmacies always sell their medical products with affordable prices and if there is a promotion, the drug will cost you quite inexpensively. Among the main positive aspects of buying the drug online are convenience, complete confidentiality, access to a wider range of products, delivery of the order to your address, low prices, much lower than in pharmacies, and the absence of queues.

On the reference online pharmacy website, you can buy Viagra with delivery to any country of the world, inexpensive and affordable. Delivery is confidential and anonymous!

Summary

Reviews of many men from social surveys say that 6 out of 10 men over the age of 30 tried to take sildenafil (Viagra) at least once in their lives, and in the end they were satisfied with the result.

It is worth noting that Viagra can be taken even by those men who do not experience problems with potency, but simply want to improve their abilities in bed, and will give their second half unforgettable memories.

Drawing a conclusion from this article, we can say that buy Viagra online is a remedy that can preserve and maintain male power and help solve the problem of potency in men of different ages. At the same time, it has a minimum of side effects and a very good and long-lasting effect.

Dr. Matt Soroush, M.D. F.A.C.S. – Pennsylvania Urologist

Dr. Matt Soroush received his bachelors degree from the University of Virginia and his medical degree from the University of Virginia School of Medicine.He served both his general surgery and urology residencies at Thomas Jefferson University. Dr. Soroush is certified by the American Board of Urology and is a Fellow of the American College of Surgeons. Dr. Soroush serves as a Clinical Instructor of Urology at Jefferson Medical College. Dr. Soroush has a special interest in the minimally invasive treatments of Urologic Oncology and Stone Disease.

EDUCATION:

• 1999-2000 Chief Resident Urology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
• 1996-2000 Resident in Urology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
• 1994-1996 Resident in General Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
• 1990-1994 Doctor of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia
• 1986-1990 Bachelor of Arts with Distinction, University of Virginia, Charlottesville, Virginia

Certification

• Pennsylvania Medical Society Continuing Medical Education Certification 6/2003
• Certification In Human Subject Research as Sponsored by The Collaborative IRB Training Initiative and The University of Miami

Societies

• Mid-Atlantic Section – American Urologic Association Society of Laparoendoscopic Surgeons
• Philadelphia Urologic Society
• Urologic Association of Pennsylvania
• Endourologic Society
• Pennsylvania Medical Society American College of Surgeons
• Millenium Urology Group

Awards & Honors

• University of Virginia Echols Scholar University of Virginia Intermediate Honors
• Alpha Epsilon Delta-University of Virginia

Clinical Research

Clinical Trials: Investigator

• Autologous PAP-Loaded Dendretic Cell Vaccine (APC 8015, Provenge) in Patients With Non- Metastatic Prostate Cancer Who Experience PSA Elevation Following Radical Prostatectomy:
• A Randomized, Controlled, Double Blind Study (Dendreon P11) A Prospective, Randomized, Controlled, Multicenter Trial of the Memokath 044TW Thermoexpandable Stent For Maintaining Urethral Patency in Patients After Dilatation or Internal Urethrotomy of Recurrent Stricture of the Bulbar Urethra (Engineers and Doctors) A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Dutasteride 0.5mg Administered Orally Once Daily for Four Years to Reduce the Risk of Biopsy-Detectable Prostate Cancer (GlaxoSmithKline)
• Study of Duloxetine HCL in Women of Different Demographic Characteristics and Comorbidities With Stress Incontinence: Evaluation of Efficacy and Safety (Eli Lilly)

BASIC SCIENCE RESEARCH:

• Student Research Fellow, Laboratory of Pathology, Tumor Invasion and Metastasis Section, National Cancer Institute, National Institutes of Health, Bethesda, Md. 1988-1991

Publications & Presentations

Peer-Reviewed Papers

• Stracke, M.L., Soroush, M., Liotta, LA, Schiffman, E: Cytoskeleton Agents Inhibit Motility and Adherence of Human Tumor Cells, Kidnay International 43: 151-157, 1993Soroush, M., Bagley, D.H., Ureteroscopic Retrograde Endopyelotomy, Techniques in Urology, 4:2, pp. 77-82, 1998
• Soroush, M., Hirsch, I.H., Das, A., Maurer, S., Multicomponent Penile Prosthesis Implantation Under Regional Anesthesia, Techniques in Urology, 5:2, 1999
• Shupp Byrne, D., Sedor, J.F., Soroush, M., McCue, P.A., Mulholland, S.G., Interaction of Bladder Glycoprotein GP51 with Uropathogenic Bacteria, The Journal of Urology, Vol. 165 pp 1342-1346, April 2001

Peer-Reviewed Abstracts

• Soroush, M., Ismail, M., Peterson, R.O., Newschaffer, C., Valicenti, R.K., Gomella, L.G., Radiation Treatment Following Radical Prostatectomy: Does It Add To Patients Morbidity? Mid-Atlantic Section, American Urologic Association Annual Meeting, W. Palm Beach, Fl., 1998

CHAPTERS AND BOOKS

• Soroush, M., ed: Urology Chapter. Surgical Recall, Lippincott, Williams and Wilkins, Philadelphia, 1993.
• Soroush, M., : (Contributor) In Gomella, L.G. and Dambro, Mark, M.D. eds, 5 Minute Urology Consult, Lippincott, Williams, and Wilkins, Philadelphia, 2000.

PRESENTATIONS AND INVITED LECTURES

• Ureteroscopic Retrograde Endopyelotomy, Thomas Jefferson University Department of Urology Grand Rounds, Philadelphia, Pa., 9/97
• Radiation Treatment Following Radical Prostatectomy: Does It Add To Patient Morbidity?, Mid-Atlantic Section, American Urologic Association, West Palm Beach, Fl. , 10/98
• Update In Erectile Dysfunction, Bryn Mawr Hospital Department of Family Medicine Lecture Series 3/01 The Use of PSA In Prostate Cancer Screening, The Bryn Mawr Hospital Department of Family Medicine Lecture Series 4/02
• Moderator, Urology Lecture Series, Department of Urology, Thomas Jefferson Universtiy, Philadelphia, Pa. 8/03
• Overactive Bladder in the Primary Care Setting, Community Lecture Series, Havertown, Pa., 1/04 Overview of the Current State of PDE5 Inhibitors in the Treatment of Erectile Dysfunction, Community Lecture Series, Devon, Pa., 2/04
• The Treatment of Erectile Dysfunction in the Primary Care Setting, Community Lecture Series, Radnor, Pa. 2/04
• Oral Therapy for Erectile Dysfunction, Community Lectue Series, Paoli, Pa., 3/04
• Benign Prostatic Hyperplasia: A Review of Medical Management, Scranton, Pa. 3/04
• The Treatment of Erectile Dysfunction in the Primary Care Setting, Bryn Mawr, Pa. 3/04 Advances In The Treatment of Interstitial Cystitis, Community Lecture Series, Haverford, Pa. 3/ 04
• The Treatment of Benign Prostatic Hyperplasia, Community Lecture Series, Reading, Pa. 4/04
• The Cardiovascular Safety Profile of PDE5 Inhibition:Fact vs. Myth, Community Lecture Series, 4/04
• The Latest Advances In Oral Therapy For Erectile Dysfunction, Community Outreach, King of Prussia, Pa. 4/04
• Benign Prostatic Hypertrophy: Management In The Primary Care Setting, Devon, Pa. 6/04